Stuart Maudsley | Pharmacology | Best Researcher Award

Posted on by Academic achievements

Prof. Dr. Stuart Maudsley | Pharmacology | Best Researcher Award

Prof. Dr. Stuart Maudsley | Pharmacology – Professor at Moffitt Cancer Center, United States

Dr. Stuart Russell Maudsley is an esteemed researcher and principal investigator whose work has had a profound impact on the field of pharmacology, particularly in the study of G-protein-coupled receptors (GPCRs). His career has been marked by significant contributions to cancer research, aging, and molecular gerontology, leading to the development of innovative therapeutic strategies aimed at treating complex human diseases. Dr. Maudsley’s work focuses on the precision targeting of GPCRs to develop treatments for a wide range of conditions, from cancer to neurodegenerative disorders, with a unique approach that blends basic science with clinical applications. He has been instrumental in leading transformative research at Moffitt Cancer Center and has earned widespread recognition for his contributions in both academia and industry.

Profile:

Scopus

Education:


Dr. Maudsley earned his Ph.D. in Pharmacology from the University of Leeds, UK, after completing a First-Class Bachelor’s degree in Pharmacology at the same institution. His doctoral research focused on electrophysiological and molecular biological studies of Tachykinin receptors, which set the stage for his continued exploration of receptor biology. His academic journey laid the groundwork for a career dedicated to uncovering the complex molecular mechanisms that regulate cellular behavior and how these processes can be manipulated for therapeutic purposes. His early education and research provided a foundation for his later innovations in the field of pharmacology and receptor therapeutics.

Experience:


Dr. Maudsley’s career spans several prestigious roles that highlight his leadership and expertise in pharmacology and receptor biology. He currently serves as the principal investigator at Moffitt Cancer Center, where he directs the Maudsley Lab, focusing on receptor biology and cancer therapeutics. His work is particularly notable for its precision in targeting GPCRs to treat cancer and other complex diseases. Dr. Maudsley also co-founded HeptOME – Receptor Therapeutics, and his position as a Special Science Advisor for the Belgian Superior Health Council reflects his international influence. His experience in both academic and industry settings has allowed him to bridge the gap between cutting-edge research and real-world therapeutic solutions.

Research Interests:


Dr. Maudsley’s primary research interest lies in the molecular and pharmacological study of GPCRs, a class of receptors that play a crucial role in various cellular processes. He focuses on understanding how these receptors regulate human diseases, particularly cancer, aging, and neurodegenerative disorders. By investigating the intricate mechanisms of GPCR signaling, Dr. Maudsley aims to develop novel targeted therapies that can improve treatment outcomes in these complex diseases. His research extends to systems pharmacology, which integrates multidimensional approaches to identify new drug targets and improve therapeutic strategies. Dr. Maudsley is particularly interested in the therapeutic application of GPCR-targeted medicines and their potential to treat diseases with unmet medical needs.

Awards:


Dr. Maudsley has received numerous accolades for his pioneering research in pharmacology and receptor biology. His work has been consistently recognized for its potential to revolutionize therapeutic strategies for cancer and aging-related diseases. He has been invited to speak at prestigious international conferences and has received several awards from scientific and medical societies for his contributions to understanding receptor biology. His recognition as a co-founder of HeptOME – Receptor Therapeutics further highlights his entrepreneurial spirit and ability to translate scientific discoveries into practical applications that benefit patients worldwide.

Publications:


Dr. Maudsley has an extensive publication record, contributing to major scientific journals and collaborative research projects. A few notable publications include:

  1. Maudsley S., Leysen H., van Gastel J., Martin B. (2021). Systems Pharmacology: Enabling Multidimensional Therapeutics, Reference Module in Biomedical Sciences. 📖
  2. Maudsley S., Schrauwen C., Harputluoğlu İ., Walter D., Leysen H., McDonald P. (2023). GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process, Int J Mol Sci. 🔬
  3. Schreurs G., Maudsley S., Nast C., Praet M., Da Silva Fernandes S., Boor P., D’Haese P., De Broe M.E., Vervaet B.A. (2023). Chronic Dehydration Induces Injury Pathways in Rats, Sci Rep. 🧪
  4. Maudsley S., Leysen H., Walter D., Vandoren R. (2023). GPCRs Regulate DNA Integrity, Encyclopedia – Biochemistry and Molecular Biology. 📑
  5. Coppens V., De Wachter O., Goossens J., Hendrix J., Maudsley S., Azmi A., van Gastel J., Van Saet A., Lauwers T., Morrens M. (2020). Profiling of Peripheral Blood Mononuclear Cells for Schizophrenia Biomarkers, Neuropsychobiology. 🧠
  6. Van Meenen J., Leysen H., Chen H., Baccarne R., Walter D., Martin B., Maudsley S. (2022). Making Biomedical Sciences Publications More Accessible for Machines, Med Health Care Philos. 💻
  7. Leysen H., Maudsley S., Van Gastel J., Martin B. (2021). The RXFP3 Receptor is a Modulator of Aging-Related Disease, Int J Mol Sci. 🧬

Conclusion:


Dr. Stuart Russell Maudsley’s extensive contributions to pharmacology, especially in the area of GPCRs and their role in complex diseases, make him an exceptional candidate for the Best Researcher Award. His research, which bridges the gap between basic science and clinical applications, continues to shape the future of precision medicine. Through his innovative work at Moffitt Cancer Center and his involvement in entrepreneurial ventures like HeptOME – Receptor Therapeutics, Dr. Maudsley has made a lasting impact on both academia and industry. His leadership in the field and his commitment to advancing therapeutic solutions for cancer, aging, and neurodegenerative diseases position him as a truly deserving nominee for this prestigious award.

Garagan Ivan | Organic chemistry | Best Researcher Award

Posted on by Academic achievements

Mr. Garagan Ivan | Organic chemistry | Best Researcher Award

Mr. Garagan Ivan | Organic chemistry-PhD at Irkutsk State University, Russia

Garagan Ivan Alexandrovich is a dedicated researcher specializing in organic chemistry, particularly in the development of oxidative sulfonamidation reactions and their application in drug design. With a deep understanding of chemical reactivity and structure, he has significantly contributed to the synthesis of biologically active compounds, focusing on the modification of unsaturated substrates and terpenes. As a member of the Federal State Research Center “Irkutsk Institute of Chemistry,” Garagan has co-authored multiple publications in leading journals and has been involved in various scientific projects funded by the Russian Science Foundation. His research has not only advanced theoretical chemistry but also has potential implications for the development of new pharmaceutical agents.

Profile:

Orcid

Education:

Garagan Ivan Alexandrovich’s educational journey began at Irkutsk State University, where he obtained his Bachelor’s degree in 2017 and Master’s degree in 2019. His academic background provided a solid foundation in organic chemistry, which he later applied in his innovative research. His dedication culminated in his successful defense of his PhD thesis in 2023, titled “Oxidative Sulfonamidation of Unsaturated Substrates – The Way to New Amidines and Heterocycles.” This work highlighted his expertise in chemical reactions that could lead to the development of novel drugs, demonstrating his potential as a leader in his field.

Experience:

Since 2019, Garagan has been an active member of the laboratory of organoelement compounds at the Irkutsk Institute of Chemistry, where he has developed expertise in organometallic chemistry and oxidation reactions. His involvement in key research projects, including those funded by the Russian Science Foundation, demonstrates his active contribution to both theoretical and practical chemistry. Over the years, Garagan has been part of a team that developed triflamidation reactions and studied the sulfonamide modification of terpenes, paving the way for new chemical methodologies with significant biological relevance. His professional experience extends to presenting his findings at conferences, where his research continues to gain recognition among peers.

Research Interests:

Garagan’s primary research interest lies in the development of oxidative sulfonamidation reactions involving unsaturated substrates, with a focus on their use in drug development. His work is centered on synthesizing biologically active compounds, including heterocycles and amidines, through selective chemical processes. This research not only contributes to the academic understanding of organic chemistry but also holds promise for the creation of new therapeutic agents. Additionally, his studies on the modification of terpenes using sulfonamide groups explore how natural compounds can be tailored to serve as the basis for novel pharmaceutical drugs. His work contributes to advancing both the basic and applied sciences within organic chemistry.

Awards:

Garagan Ivan Alexandrovich has been recognized for his outstanding contributions to organic chemistry. His active participation in high-profile scientific conferences, such as the “Actual Problems of Organic Chemistry” conference in 2024, showcases his commitment to sharing his research with the broader scientific community. Furthermore, his involvement in two Russian Science Foundation grants demonstrates the significance of his work in advancing chemical research. These grants, focused on amidation of monoterpenes and the development of new heterocyclic compounds, highlight Garagan’s integral role in groundbreaking scientific endeavors.

Publications:

Garagan has authored and co-authored several key publications in high-impact journals, contributing significantly to the field of organic chemistry. Some of his notable works include:

  1. “Halosulfonamidation of Camphene: Chemo and Stereoselectivity, Rearrangement, Solvent Interception, Heterocyclization” (2024) in New Journal of Chemistry
    DOI: 10.1039/D4NJ02582B
    This article discusses the chemo and stereoselectivity of halosulfonamidation reactions in camphene, exploring the mechanisms and solvent effects.
  2. “N-(4-Iodo-1,3-diphenylbutyl)acetamide: Nature and Strength of Hydrogen Bonds in Crystal and Solutions” (2023) in Russian Journal of General Chemistry
    DOI: 10.1134/S1070363223100225
    This publication focuses on the analysis of hydrogen bonds in crystal structures, offering insights into molecular interactions.
  3. “Synthesis and Structure of N-(1-(Bromomethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-yl)benzenesulfonamide” (2023) in MolBank
    DOI: 10.3390/M1645
    The article presents the synthesis and characterization of a novel sulfonamide compound with potential applications in drug design.
  4. “Regioselective Oxidative Halotriflamidation of Dienes and Trienes as a Route to New Amidines and Heterocycles” (2022) in ChemistrySelect
    DOI: 10.1002/SLCT.202202231
    This paper outlines the selective triflamidation of dienes and trienes, contributing to the development of new heterocyclic compounds.
  5. “Triflamidation of Allyl-Containing Substances: Unusual Dehydrobromination vs. Intramolecular Heterocyclization” (2022) in Molecules
    DOI: 10.3390/MOLECULES27206910
    This article discusses the triflamidation of allyl substances, providing insights into unusual reaction pathways and potential applications in chemical synthesis.
  6. “Oxidative Sulfonamidation of O-containing Vinylsilanes. A New Route to Novel Heterocycles and Amidines” (2021) in Journal of Organometallic Chemistry
    DOI: 10.1016/J.JORGANCHEM.2021.122010
    The study investigates new oxidative sulfonamidation routes for synthesizing heterocycles, showcasing novel methodologies for organic synthesis.
  7. “Solvent-Dependent Oxidative Triflamidation of Alkenes and N(O)-Heterocyclization of the Products” (2021) in Tetrahedron
    DOI: 10.1016/J.TET.2021.132145
    This paper explores the solvent-dependent oxidative triflamidation of alkenes, contributing to the understanding of solvent effects on chemical reactions.

Conclusion:

Garagan Ivan Alexandrovich is a distinguished researcher whose work has advanced the field of organic chemistry, particularly in the synthesis of biologically active compounds and the development of new chemical reactions for drug discovery. His contributions to oxidative sulfonamidation and heterocyclization have the potential to impact various areas, including pharmaceutical development and medicinal chemistry. His active participation in high-impact research projects, collaboration with leading researchers, and significant publications solidify his reputation as a leader in his field. As a promising scientist with a bright future, Garagan’s innovative contributions make him a worthy candidate for the Best Researcher Award, and his continued research is likely to further shape the future of organic chemistry and drug development.